Title:Diagnosis accuracy of cardiac myosin-binding protein C for acute myocardial infarction

Author:Kambiz Masoumi, Arash Forouzan, Hassan Motamed, Habib Heybar, Nastaran Ranjbari and Sepideh Mohajer Shirazi

Abstract:Background: Acute myocardial infarction (AMI) leads to increased mortality and recurrent ischemia and should be diagnosed promptly and distinguished from other causes of chest pain. It is necessary to evaluate the accuracy of cardiac myosin-binding protein (cMyC) to identify it a useful biomarker in the early diagnosis of AMI patients.
Methods: Participants diagnosed with AMI were confirmed based on clinical findings and electrocardiography and increased cardiac troponin 1 (cTn1) levels in the Emergency Department of Ahvaz Golestan Imam Khomeini Hospitals, Iran during the 2018 year. A complete blood count, serum glucose, cTn1, blood urea nitrogen, creatinine, sodium, potassium, and serum levels of cardiac myosin-binding protein (cMyC) were measured. The patients were followed up for 24 hours.
Results: Sixty-five patients with AMI were included in the study of whom 64.6% were ST-elevation myocardial infarction. The value of AUC = 1.00 (95% CI: 1.00-1.00) indicated that the CMyBP-C marker fully and correctly identified AMI individuals. At a significance level of 5%, the P-value <0.001 indicated that the CMyBP-C marker has an excellent ability to differentiate AMI.
Conclusion: Our study showed that the cMyC biomarker was significantly higher in AMI patients at all studied times and had a high diagnostic accuracy in diagnosing patients with AMI.
Keywords: cardiovascular disease; myocardial ischemia; acute myocardial infarction; myosin-binding protein c; diagnosis.
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