Title:New diagnostic biomarkers for celiac disease in Egyptian children: Cyclophilin A and Netrin-1

Author:Moushira Zaki, Eman R Youness and Hala T El-Bassyouni

Abstract:Background: Celiac disease is a chronic inflammatory disease of the small intestine. Cyclophilin A (CYPA) is a highly abundant protein in the cytoplasm of most mammalian cells. Netrin-1 is a laminin-related secreted protein that is broadly expressed in numerous tissues. Our aim was to determine the efficiency of both markers in the diagnosis of celiac disease and their relations to clinical findings.
Methods: This study was conducted on 50 children (mean age: 8±3.2 years) with celiac disease and 48 age and sex matched healthy controls. Circulating serum CYPA, Netrin-1, and anti-tissue transglutaminase antibodies were measured using ELISA kit.
Results: Both markers were significantly higher in celiac disease patients compared to controls. Patients presented with low birthweight in 5%, 15% of the patients were the offspring of consanguineous families, delayed milestones in 10%, abdominal pain in 35%, diabetes Type 1 was found in 10%, all patients had increased antitissue glutaminase levels, and upper endoscopy lesions in 25%. Significant positive correlations were noted between anti-tissue transglutaminase antibodies and both markers.
Conclusion: Both markers had good diagnostic performance for celiac disease among Egyptian children.
Keywords: Celiac Disease; Diagnosis; Cyclophilin A; Netrin-1.
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