Title:Brain derived neurotrophic factor, oxidative stress status and vitamin D levels in patients with autism spectrum disorder

Author:Moushira Zaki, Hala T. El-Bassyouni, Khaled Hamed, Rehab Selim Ismail Moustafa and Eman R. Youness

Abstract:Background: Brain Derived Neurotrophic Factor (BDNF) may play a role in the progression and development of the autism spectrum disorder (ASD). The aim of the study was to evaluate oxidative stress marker malondialdehyde (MDA), vitamin D status (serum 25-hydroxy vitamin D) and brain-derived neurotrophic factor (BDNF) in children with autism and elucidate whether there is a correlation between the severity of the disease and the level of the BDNF.
Patients and methods: 94 children with ASD (75 males and 19 females) and 72 healthy controls matched in age were enrolled. The oxidative stress markers were measured by evaluating serum levels of MDA, 25 - hydroxy vitamin D in patients and controls and BDNF concentrations were measured.
Results: Vitamin D (25(OH)-D) was statistically lower in the patients compared to controls (P <0.006). The MDA and BDNF serum levels were statistically higher in children with ASD (P < 0.001) related to the control group. The BDNF levels correlated with the severity of the disease.
Conclusion: The levels of BDNF could be considered a diagnostic or prognostic indicator of ASD, it is recommended to evaluate its role in the onset and progression of this disorder. Our study sheds light on the importance of supplementation of ASD patients with antioxidants and Vitamin D as it may help in the amelioration of their symptoms.
Keywords: Autism spectrum disorder (ASD), brain-derived neurotrophic factor (BDNF), malondialdehyde, oxidative stress, Vitamin D (25(OH)-D)
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