Title:Netrin-1 and Cyclophilin A (CypA): biomarkers of inflammation and kidney injury in Alport syndrome: a pilot study

Author:Moushira Zaki, Fatina I. Fadel, Safinaz Ebrahim El-Toukhy, Eman R. Youness, Abeer Selim, Mohamed EL-Sonbaty and Hala T. El-Bassyouni

Abstract:Background: Netrin-1 and Cyclophilin A (CypA) participate in the pathological processes of inflammation, oxidative stress and apoptosis. Our objective was to determine the level of serum Netrin-1 & Cyclophilin A (CypA) in Alport syndrome.
Materials and Methods: The study included 10 Alport syndrome patients, their age ranged from 5-13 years (8.50±2.87) (mean age ±SD), they were 7 females and 3 males (ratio of 1:0.43) and 10 age and sex matched healthy children. Serum Netrin-1 and Cyclophilin A (CypA) were measured using ELISA kits.
Results: All patients presented with haematuria, while 3 cases had mild proteinuria. The renal pathology revealed features like thin basement membrane disease. Sensorineural hearing loss was present in 8 patients and no patients had retinitis pigmentosa. The serum levels of Netrin-1 were 160.47ng/mL ± 12.833 for controls and 141.91ng/mL ±16.953 for patients (p < 0.01), for CypA was 7.55ng/mL ±0.74 in patients compared to 6.27ng/mL ±0.37 in controls (p<0.001).
Conclusion: To the best of our knowledge, this is the first research to investigate the levels of Netrin-1 and Cyclophilin A in Alport syndrome patients.
Keywords: Alport syndrome, Cyclophilin A (CypA), Netrin-1, inflammation.
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