Title:Serum biomarkers and transient elastography versus histopathology for assessment of post living donor liver transplantation (LDLT) Hepatitis C virus recurrence

Author:Wafaa M Ezzat, Olfat Gamil Shaker, Mohamed Said Abdelaziz, Amr Mohamed Farag and Ayman Yosry Abdelrehim

Abstract:This study aimed to detect fibrosis in Hepatitis C virus (HCV) infected liver transplant recipients using serum markers and Fibroscan, and to validate the diagnostic accuracy of these non-invasive methods in comparison with liver biopsy.
Patients and methods: Twenty-five consecutive patients with Hepatitis C virus related end-stage liver disease who underwent living donor liver transplantation (LDLT) were scheduled for assessment of hepatic fibrosis through assaying serum fibromarkers, fibroscan and protocol liver biopsy after liver transplantation to examine Hepatitis C virus recurrence and to assess stage of fibrosis and histological activity index using Metavir score.
Results: It was found that Fibrosis-4 index (FIB-4) showed good concordance to liver biopsy examination as regards F1. On the other hand, there was no concordance of FIB-4 to other grades of liver fibrosis. Age to Platelet Ratio Index (APRI) showed excellent concordance to liver biopsy examination as regards different grades of liver fibrosis. Excellent concordance to liver biopsy examination was found considering serum values of Hyaluronic Acid (HA). Liver stiffness measurement by Fibroscan agreed with pathological examination of liver biopsies results in 44% of cases.
Conclusion: Non-invasive techniques as serum biomarkers and fibroscan may predict recurrence of hepatitis and liver fibrosis among chronic Hepatitis C virus patients who underwent living donor liver transplantation. Non-invasive markers including APRI score and HA can predict liver fibrosis precisely.
Key words: HCV, Living donor liver transplantation (LDLT), Serum markers, Fibroscan, Liver fibrosis.
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