Title:Optimal cut off point of the triglyceride to HDL-C ratio for insulin resistance among Egyptian obese premenopausal women: a cross-sectional study

Author:Moushira Zaki, Wafaa Kandeel and Eman Refaat Youness

Abstract:Background: Previous research suggested that the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) could be a straightforward clinical diagnostic of insulin resistance (IR), but the findings showed that there were differences between different ethnic groups.
Objective: This study aimed to determine an optimal cut off point of TG/HDL-C ratio for IR among premenopausal obese women. Methods: A total of 220 blood samples of premenopausal obese women were analysed for fasting glucose, lipids and insulin. They were divided into an insulin resistance (IR) group and a non-insulin resistance group, using homeostasis model assessment (HOMA). A receiver operating characteristic (ROC) analysis was conducted to evaluate the ability of the developed clinical prediction rule to correctly discriminate between subjects of insulin resistance (IR) positive and insulin resistance negative groups.
Results: The optimal cut off point of triglycerides to HDL-C ratio with was 3.39, with a sensitivity of 88.89% and specificity of 76.27% (AUC=0.854) which was significant, with a p-value lower than 0.001.
Conclusion: Triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be used as a reliable marker for insulin
resistance among premenopausal obese women.
Keywords: Insulin resistance, TG/HDL-C ratio, cut off point, obese women
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