Title:Chemerin: an exploitable biomarker for familial Mediterranean fever in Egyptian patients

Author:Hala T El-Bassyouni, Hisham Megahed, Eman R Youness, Hisham A Aziz Orban, Maha M Kobesiy, Rania A Ellethy, Mina Wassef Girgiss, Adel Mohamed Ashour, Ahmed Helal El Sayed and Moushira E Zaki

Abstract:Aim: The most prevalent autoinfammatory condition, Familial Mediterranean Fever (FMF), is characterized by persistent, subclinical infammation. Chemerin plays a role in infammation. The aim of the work is to assess if Chemerin can be used as a diagnostic index in Familial Mediterranean Fever patients.
Methods: A total of 66 Familial Mediterranean Fever patients and 60 controls matching age and sex were enrolled in the study. Serum
Chemerin, vitamin D3, oxidized LDL, lipid profile and Amyloid A were assessed by ELISA assay.
Results: Chemerin level which suggested chronic infammation, was significantly elevated as compared to the controls. The Familial Mediterranean Fever patients had highly significant levels of total cholesterol, total triglycerides and LDL, while the HDL significantly inversely correlated in the Familial Mediterranean Fever patients compared to controls. Moreover, the vitamin D level was significantly lower in Familial Mediterranean Fever patients.
Conclusion: Chemerin that acts as a pro-infammatory adipokine, could be a novel biomarker refecting the chronic pro-infammatory status in the Familial Mediterranean Fever patients and may facilitate the development of Chemerin as a new therapeutic modality in the treatment of Familial Mediterranean Fever. Furthermore, vitamin D supplementation is recommended in the Familial Mediterranean Fever patients.
Keywords: Familial Mediterranean Fever, Chemerin, Vitamin D3, Lipid Profile
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